Public Health Intelligence

Disease Burden & Diagnostic Gaps

Regional disease burden data, outbreak status, and diagnostic gap analysis by pathogen. Data sourced from WHO, CDC, PAHO, and ECDC.

Critical Diagnostic Gaps

Active Outbreak Regions

Regions Tracked

Pathogen-Region Records

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58 of 58 records

Pathogen	Region / Country	Incidence /100k	Mortality /100k	Est. Cases/yr	Outbreak Status	Diagnostic Gap	Tests Available	Source
Mycobacterium tuberculosis Bacteria	Sub-Saharan Africa	290	38	2.1M	Endemic	Critical	6 2023	WHO GTB
Mycobacterium tuberculosis Bacteria	Sub-Saharan Africa	290	38	2.1M	Endemic	Critical	6 2023	WHO GTB
Mpox virus Virus	Sub-Saharan Africa DRC	28	3.8	22K	Active	Critical	3 2024	WHO
Ebola virus Virus	Sub-Saharan Africa DRC	0.4	0.3	342	Sporadic	Critical	2 2023	WHO
Plasmodium spp. Parasite	Sub-Saharan Africa	380	52	247.0M	Endemic	Critical	5 2023	WHO GMP
Mpox virus Virus	Sub-Saharan Africa DRC	28	3.8	22K	Active	Critical	3 2024	WHO
Ebola virus Virus	Sub-Saharan Africa DRC	0.4	0.3	342	Sporadic	Critical	2 2023	WHO
Chlamydia trachomatis Bacteria	Global	380	0	129.0M	Endemic	High	10 2023	WHO
Chlamydia trachomatis Bacteria	Global	380	0	129.0M	Endemic	High	10 2023	WHO
Neisseria gonorrhoeae Bacteria	Global	82	0.1	82.0M	Endemic	High	9 2023	WHO GASP
Klebsiella pneumoniae Bacteria	Global	12	4.2	700K	Endemic	High	8 2023	WHO GLASS
Klebsiella pneumoniae Bacteria	Global	12	4.2	700K	Endemic	High	8 2023	WHO GLASS
Neisseria gonorrhoeae Bacteria	Global	82	0.1	82.0M	Endemic	High	9 2023	WHO GASP
Mpox virus Virus	Global	0.8	0.1	92K	Active	High	5 2024	WHO
Mpox virus Virus	Global	0.8	0.1	92K	Active	High	5 2024	WHO
Dengue virus Virus	Latin America	190	1.8	4.2M	Active	High	7 2023	PAHO
Dengue virus Virus	Latin America	190	1.8	4.2M	Active	High	7 2023	PAHO
Mycobacterium tuberculosis Bacteria	South & Southeast Asia India	210	22	2.8M	Endemic	High	8 2023	WHO GTB
Dengue virus Virus	South & Southeast Asia	280	2.1	100.0M	Active	High	8 2023	WHO
Plasmodium spp. Parasite	South & Southeast Asia	28	4.1	4.8M	Endemic	High	7 2023	WHO GMP
Mycobacterium tuberculosis Bacteria	South & Southeast Asia India	210	22	2.8M	Endemic	High	8 2023	WHO GTB
Dengue virus Virus	South & Southeast Asia	280	2.1	100.0M	Active	High	8 2023	WHO
Plasmodium spp. Parasite	South & Southeast Asia (P. vivax)	18	0.8	3.2M	Endemic	High	6 2023	WHO GMP
Hepatitis B virus Virus	Sub-Saharan Africa	65	18	82.0M	Endemic	High	9 2023	WHO GHSS
Hepatitis B virus Virus	Sub-Saharan Africa	65	18	82.0M	Endemic	High	9 2023	WHO GHSS
HIV-1/2 Virus	Sub-Saharan Africa	280	42	1.2M	Endemic	High	12 2023	UNAIDS/WHO
Influenza B Virus	Global	350	3.2	300.0M	Endemic	Moderate	18 2023	WHO FluNet
Influenza A Virus	Global	1,100	9.8	1.0B	Endemic	Moderate	22 2023	WHO FluNet
Hepatitis C virus Virus	Global	23	4.8	58.0M	Endemic	Moderate	11 2023	WHO GHSS
Streptococcus pneumoniae Bacteria	Global	1,800	5.2	700.0M	Endemic	Moderate	12 2023	WHO
Influenza B Virus	Global	350	3.2	300.0M	Endemic	Moderate	18 2023	WHO FluNet
RSV Virus	Global	620	8.9	33.0M	Endemic	Moderate	10 2023	WHO
Influenza A Virus	Global	1,100	9.8	1.0B	Endemic	Moderate	22 2023	WHO FluNet
Hepatitis C virus Virus	Global	23	4.8	58.0M	Endemic	Moderate	11 2023	WHO GHSS
Klebsiella pneumoniae Bacteria	North America USA	8.4	2.8	28K	Endemic	Moderate	11 2023	CDC NHSN
Klebsiella pneumoniae Bacteria	North America USA	8.4	2.8	28K	Endemic	Moderate	11 2023	CDC NHSN
HIV-1/2 Virus	South & Southeast Asia	8.2	3.1	380K	Endemic	Moderate	10 2023	WHO SEARO
Hepatitis B virus Virus	Western Pacific	58	12	115.0M	Endemic	Moderate	14 2023	WHO GHSS
Hepatitis B virus Virus	Western Pacific	58	12	115.0M	Endemic	Moderate	14 2023	WHO GHSS
Clostridioides difficile Bacteria	Europe	98	7.4	124K	Endemic	Low	9 2023	ECDC
Clostridioides difficile Bacteria	Europe	98	7.4	124K	Endemic	Low	9 2023	ECDC
SARS-CoV-2 Virus	Global	420	8.2	33.0M	Endemic	Low	45 2023	WHO
SARS-CoV-2 Virus	Global	420	8.2	33.0M	Endemic	Low	45 2023	WHO
Clostridioides difficile Bacteria	North America USA	142	9.2	462K	Endemic	Low	11 2023	CDC
Chlamydia trachomatis Bacteria	North America USA	495	0	1.6M	Endemic	Low	15 2023	CDC
RSV Virus	North America USA	580	6.1	2.1M	Endemic	Low	14 2023	CDC
HIV-1/2 Virus	North America USA	11.4	1.8	37K	Endemic	Low	18 2023	CDC
Chlamydia trachomatis Bacteria	North America USA	495	0	1.6M	Endemic	Low	15 2023	CDC
Neisseria gonorrhoeae Bacteria	North America USA	192	0.1	677K	Endemic	Low	14 2023	CDC
Streptococcus pneumoniae Bacteria	North America USA	2,100	3.8	700K	Endemic	Low	16 2023	CDC
Mycobacterium tuberculosis Bacteria	North America USA	2.9	0.2	10K	Sporadic	Low	15 2023	CDC
SARS-CoV-2 Virus	North America USA	380	6.4	1.2M	Endemic	Low	38 2023	CDC
Influenza A Virus	North America USA	1,400	8.5	35.0M	Endemic	Low	28 2023	CDC FluView
Clostridioides difficile Bacteria	North America USA	142	9.2	462K	Endemic	Low	11 2023	CDC
SARS-CoV-2 Virus	North America USA	380	6.4	1.2M	Endemic	Low	38 2023	CDC
Influenza A Virus	North America USA	1,400	8.5	35.0M	Endemic	Low	28 2023	CDC FluView
Mycobacterium tuberculosis Bacteria	North America USA	2.9	0.2	10K	Sporadic	Low	15 2023	CDC
Neisseria gonorrhoeae Bacteria	North America USA	192	0.1	677K	Endemic	Low	14 2023	CDC

Diagnostic Gap Legend

Critical — Severe shortage of available diagnostics; significant unmet clinical need

High — Limited test availability relative to disease burden

Moderate — Some diagnostic options exist but access or performance gaps remain

Low — Adequate diagnostic coverage for the disease burden

Incidence and mortality rates are per 100,000 population. Estimated cases per year are annual figures from the most recent data year. Data is illustrative and sourced from WHO GHO, CDC, PAHO, and ECDC publications.